A drug has been shown to extend the lifespan of laboratory mice by nearly 25%, with treated mice displaying fewer cancers and improved health and strength. It earned them the nickname “supermodel grannies” due to their youthful appearance. “The drug is already being tested in people, but whether it would have the same anti-ageing effect is unknown,” reports the BBC. From the report: The team at the MRC Laboratory of Medical Science, Imperial College London and Duke-NUS Medical School in Singapore were investigating a protein called interleukin-11. Levels of it increase in the human body as we get older, it contributes to higher levels of inflammation, and the researchers say it flips several biological switches that control the pace of ageing.
The researchers performed two experiments. The first genetically engineered mice so they were unable to produce interleukin-11. The second waited until mice were 75 weeks old (roughly equivalent to a 55-year-old person) and then regularly gave them a drug to purge interleukin-11 from their bodies. The results, published in the journal Nature, showed lifespans were increased by 20-25% depending on the experiment and sex of the mice.
Old laboratory mice often die from cancer, however, the mice lacking interleukin-11 had far lower levels of the disease. And they showed improved muscle function, were leaner, had healthier fur and scored better on many measures of frailty.